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2‐HYDROXYIMINOMETHYL‐ N ‐METHYLPYRIDINIUM METHANESULPHONATE AND ATROPINE IN THE TREATMENT OF SEVERE ORGANOPHOSPHATE POISONING
Author(s) -
DAVIES D. R.,
GREEN A. L.,
WILLEY G. L.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00920.x
Subject(s) - atropine , oxime , sarin , organophosphate , chemistry , organophosphate poisoning , accidental poisoning , pharmacology , toxicology , anesthesia , medicine , poison control , biochemistry , acetylcholinesterase , pesticide , biology , emergency medicine , injury prevention , agronomy , enzyme
The soluble methanesulphonate of the oxime 2‐hydroxyiminomethyl‐ N ‐methylpyridinium (P2S) has been used to treat animals poisoned with sarin or ethyl pyrophosphate. The effect of the size of the dose, and its time of administration in relation to poisoning, have been examined. This oxime is very efficient in conjunction with atropine when given either before or after poisoning. About 30 mg./kg. seems to be the optimum therapeutic dose of the methanesulphonate. The significance of this optimum is discussed in relation to the treatment of accidental poisoning by organophosphate insecticides in man.