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THE ACTION OF ANTISYMPATHOMIMETIC DRUGS ON THE URINARY EXCRETION OF ADRENALINE AND NORADRENALINE
Author(s) -
BENFEY B. G.,
LEDOUX G.,
SEGAL M.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00262.x
Subject(s) - phenoxybenzamine , phentolamine , norepinephrine , blood pressure , excretion , endocrinology , medicine , urinary system , diuresis , chemistry , ethanolamines , cats , vasopressin , kidney , propranolol , dopamine , biochemistry , ethanolamine
In cats anaesthetized with pentobarbitone sodium, phenoxybenzamine, dibenamine, phentolamine, and piperoxane reduced the blood pressure and increased the urinary excretion of noradrenaline. When the fall of blood pressure after phenoxybenzamine was prevented by repeated injections of vasopressin, the urinary excretion of noradrenaline did not rise. Hydergine and hydrallazine reduced the blood pressure without raising the urinary excretion of noradrenaline. In dogs, the infusion of small amounts of noradrenaline led to a significantly higher urinary recovery of the amine after phenoxybenzamine than before. It is concluded that anti‐sympathomimetic drugs interfere with the destruction in the body of noradrenaline, whether released reflexly in hypotension or injected.