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MECHANISM OF ACTION OF ORAL ANTI‐DIABETIC DRUGS
Author(s) -
AIMAN RANITA,
CHAUDHARY NIRMALA
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00261.x
Subject(s) - alloxan , blood sugar , insulin , drug , diabetes mellitus , medicine , mechanism of action , pharmacology , endocrinology , distilled water , chemistry , biochemistry , chromatography , in vitro
The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1% ± 2.9 s.e.) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8% ± 2.0) or distilled water given 24 hr. (7.7% ± 1.3) respectively after the last dose of insulin. It is postulated that the drug acts by liberating bound insulin in the plasma.