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THE PHARMACOLOGY OF THE ETHANESULPHONATE ANION
Author(s) -
GOODFORD P. J.,
ING H. R.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00257.x
Subject(s) - sodium , chloride , chemistry , saline , ileum , ion , membrane , biophysics , pharmacology , biochemistry , endocrinology , biology , organic chemistry
A method of preparing analytically pure sodium ethanesulphonate, C 2 H 5 SO 3 Na.H 2 O, in quantity is described. Physiological saline solutions were prepared in which a proportion of the sodium chloride normally present was replaced by an equimolar concentration of sodium ethanesulphonate. The effects of partial or total replacement of sodium chloride were examined upon a series of isolated organs, and the guinea‐pig ileum preparation was found to be particularly sensitive to the change. Evidence is presented that these low‐chloride solutions depolarized the cell membrane of smooth muscle, and that this effect might have been due to an alteration of the chloride ion potential.