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OUABAIN‐INDUCED VENTRICULAR TACHYCARDIA AND ITS EFFECT ON THE PERFORMANCE AND METABOLISM OF THE DOG HEART
Author(s) -
FAWAZ G.,
TUTUNJI B.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00256.x
Subject(s) - ouabain , phosphocreatine , tachycardia , medicine , strophanthin , cardiology , ventricular tachycardia , heart rate , hypoxia (environmental) , coronary sinus , stimulation , sinus tachycardia , oxygen , blood pressure , endocrinology , chemistry , energy metabolism , sodium , organic chemistry
At constant pressure work there was an increase in the oxygen consumption of the dog heart‐lung preparation after tachycardia due to auricular stimulation and a far greater increase in consumption after ouabain‐induced ventricular tachycardia, as compared with control hearts beating at their own sinus rhythm. In neither condition was the increase in coronary flow greater than the spontaneous increase in the controls. It is suggested that an increase in oxygen demand, under certain circumstances, may be met primarily by an increased desaturation of coronary blood. “Therapeutic” doses of ouabain did not improve the mechanical efficiency of the preparation. “Toxic” doses of ouabain which gave rise to ventricular tachycardia did not decrease the phosphocreatine or labile nucleotide phosphorus content of the heart provided there was no hypoxia of the heart muscle.