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A COMPARATIVE STUDY OF THE EFFECTS OF DRUGS ON THE AROUSAL SYSTEM OF THE BRAIN
Author(s) -
BRADLEY P. B.,
KEY B. J.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00254.x
Subject(s) - arousal , stimulation , reticular formation , reticular activating system , chlorpromazine , neuroscience , afferent , sensory system , psychology , medicine , pharmacology
The effects of twelve drugs, eleven of which are reported to be tranquillizers, have been studied in relation to thresholds for arousal produced both by direct stimulation of the brain stem reticular formation and also by afferent nerve stimulation. The drugs can be grouped according to whether (a) like chlorpromazine they produce a slight rise in thresholds for brain stem stimulation and block sensory‐induced arousal, (b) cause dissociation between behaviour and electrical activity of the brain, (c) have no effects on thresholds for brain stem stimulation and only slight effects on afferent nerve‐induced arousal or (d) have no effect on arousal responses at all.