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THE ACTION OF TUBOCURARINE ON CILIARY MOVEMENT
Author(s) -
MILTON A. S.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00251.x
Subject(s) - d tubocurarine , calcium , chemistry , bicarbonate , physostigmine , cilium , atropine , phosphate , biophysics , ringer's solution , acetylcholine , endocrinology , pharmacology , biochemistry , biology , organic chemistry , microbiology and biotechnology
Further investigation of the effect of tubocurarine on the transport of particles by cilia of the frog oesophagus has confirmed that, when Ringer solution buffered with bicarbonate was used, tubocurarine inhibited the movement in a concentration of 10 −6 g./ml. If, however, Ringer solution with a phosphate buffer was used tubocurarine was without effect. The difference in action is probably due to changes in calcium ion concentration caused by the phosphate in the Ringer solution.