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THE CHROMATOGRAPHIC BEHAVIOUR OF WASP VENOM KININ, KALLIDIN AND BRADYKININ
Author(s) -
MATHIAS A. P.,
SCHACHTER M.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00912.x
Subject(s) - kinin , kallidin , bradykinin , venom , chemistry , chromatography , kallikrein , homogeneous , chymotrypsin , biochemistry , trypsin , enzyme , receptor , physics , thermodynamics
Wasp venom kinin which has hitherto appeared to be homogeneous can be resolved by ion‐exchange chromatography into a single major and two minor components. These are indistinguishable by their action on smooth muscle and by their rapid inactivation by chymotrypsin. All three components of wasp kinin are chromatographically different from kallidin or bradykinin. The close similarity of the latter compounds is confirmed by their identical behaviour on an ion‐exchange resin.