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THE EFFECT OF SUBSTANCE P ON THE PERISTALTIC REFLEX OF THE ISOLATED GUINEA‐PIG ILEUM
Author(s) -
BELESLIN D.,
VARAGIĆ V.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00911.x
Subject(s) - peristalsis , substance p , hexamethonium , reflex , guinea pig , ileum , chemistry , medicine , lumen (anatomy) , peristaltic pump , endocrinology , anatomy , receptor , neuropeptide , physics , meteorology
The introduction of substance P into the lumen of the isolated guinea‐pig ileum caused an increase in the number and amplitude of the peristaltic waves. In preparations in which the peristaltic reflex was abolished, by fatigue, by external or internal application of 5‐hydroxytryptamine, or by lowering the temperature of the bath, the introduction of substance P into the lumen of the intestine restored peristalsis. This effect of substance P was absent in preparations in which the mucous membrane was removed. Hexamethonium abolished the effect of substance P on peristalsis. It is concluded that substance P acts on the afferent nervous elements of the peristaltic reflex arc, possibly on the sensory receptors.