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PHARMACOLOGICAL PROPERTIES OF ββ‐DIMETHYL‐ACRYLOYLCHOLINE AND SOME OTHER β‐SUBSTITUTED ACRYLOYLCHOLINES
Author(s) -
HOLMSTEDT B.,
WHITTAKER V. P.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00908.x
Subject(s) - potency , chemistry , pharmacology , choline , respiratory system , stimulant , stereochemistry , biochemistry , in vitro , medicine
The mammalian pharmacology of a new naturally occurring ester of choline, ββ‐dimethyl‐acryloylcholine (DMAC), has been studied, mainly in the cat, together with that of two synthetic β‐substituted acryloylcholines, crotonoylcholine and pent‐2‐enoylcholine. Comparisons have been made with the reduced form of DMAC, iso valerylcholine, with another naturally occurring β‐substituted acryloylcholine, murexine (urocanoylcholine), and with suxamethonium. DMAC has been shown to be a ganglion stimulating and neuromuscular blocking agent generally similar, in potency and properties, to murexine. It is also a powerful respiratory stimulant. The other unsaturated esters behaved similarly but were less potent.