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THE TRYPANOCIDAL ACTIVITY OF SOME PYRIMIDYL‐AMINOPHENYLARSONIC COMPOUNDS
Author(s) -
AINLEY A. D.,
DAVEY D. G.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00898.x
Subject(s) - chemistry , trypanocidal agent , trypanosomiasis , biochemistry , pharmacology , biology , virology , trypanosoma brucei , gene
A series of substituted pyrimidylaminophenylarsonic acids have been prepared, reduced to the corresponding oxophenylarsines and finally, in certain cases, to the arsenobenzenes. The tervalent arsenicals were highly active against Trypanosoma rhodesiense in mice. 4‐(2:6‐Diaminopyrimid‐4‐ylamino)phenyloxoarsine either as the insoluble carbonate or the soluble isethionate was the most promising of these compounds.