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THE PHARMACOLOGICAL ACTIONS OF SOME MUREXINE‐LIKE SUBSTANCES
Author(s) -
ERSPAMER V.,
GLÄSSER A.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00224.x
Subject(s) - choline , chemistry , imidazole , nicotine , pharmacology , biochemistry , stereochemistry , biology , neuroscience
Four choline esters of imidazole acids, two imidazole ethers of choline and thirteen ring‐substituted murexine‐like compounds were compared with murexine for their muscle‐paralysing and their nicotine‐like effects. Dihydromurexine appeared, in animal experiments, to be the most potent derivative, but it was shown to be less effective than murexine in man. Among the other compounds, imidazolebutyrylcholine and imidazolepropoxycholine appeared to be worthy of particular consideration. The relation between the chemical structure of the murexine‐like substances studied and their pharmacological effects is discussed.