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EFFECTS OF RATE OF STIMULATION AND OF FATIGUE ON THE RESPONSE TO NEUROMUSCULAR BLOCKING AGENTS
Author(s) -
WISLICKI L.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00208.x
Subject(s) - stimulation , neuromuscular blocking agents , stimulus (psychology) , medicine , blocking effect , muscle contraction , anesthesia , block (permutation group theory) , blocking (statistics) , psychology , computer science , mathematics , geometry , developmental psychology , psychotherapist , computer network
The response to neuromuscular blocking agents, as exemplified by suxamethonium and tubo‐curarine, may differ between symmetrical muscles. Increased rates of stimulation and fatigue both increase sensitivity to blocking agents. During recovery from suxamethonium block muscles may show a transitory failure to react to each stimulus with a contraction. Fatigue caused by prolonged indirect stimulation is prevented equally well by suxamethonium and tubocurarine in doses producing a complete block. The mechanism and significance of these findings are discussed.