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VASOACTIVE SUBSTANCES IN THE NASAL MUCOSA
Author(s) -
TOH C. C.,
MOHIUDDIN A.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00204.x
Subject(s) - histamine , mucous membrane of nose , acetylcholine , potassium permanganate , chemistry , substance p , gastric mucosa , osmium tetroxide , intestinal mucosa , endocrinology , medicine , pharmacology , biochemistry , anatomy , biology , neuropeptide , stomach , electron microscope , physics , optics , receptor , organic chemistry
Besides histamine another smooth muscle stimulating substance has been found in the nasal mucosa of dog and sheep. It is an acid which is readily oxidized by neutral aqueous potassium permanganate and osmium tetroxide, and is thermostable at p H 10·8 but not at p H 2·8. The purification of this acid has been followed by using the atropinized tortoise intestine as a test object, which is insensitive to acetylcholine, 5‐hydroxytryptamine and small amounts of histamine. Both the tortoise intestine and rat colon are contracted by this acidic substance. The amount of histamine found in sheep nasal mucosa ranged from 12 to 23 μg./g. tissue and in dog nasal mucosa from 6 to 13 μg./g. tissue.