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CHRONIC TOXICITY OF DEXTRAN SULPHATE IN RABBITS
Author(s) -
HINT H. C.,
RICHTER A. W.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00203.x
Subject(s) - toxicity , dextran , heparin , cachexia , osteoporosis , anticoagulant , medicine , body weight , pharmacology , chemistry , endocrinology , biochemistry , cancer
The chronic toxicities of two samples of low molecular dextran sulphate from different sources were studied in rabbits. Both samples caused retardation in weight gain, cachexia and general osteoporosis with spontaneous fractures and epiphyseolyses. Heparin‐treated controls were used to exclude the possibility that the toxic effects could be connected with prolonged anticoagulant treatment. It is concluded that prolonged administration of dextran sulphate causes systemic toxic effects which are not related to its anticoagulant activity.