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A COMPARISON OF ANTIFIBRILLATORY DRUGS IN THE HEART‐LUNG PREPARATION
Author(s) -
RAND M. J.,
WALKER J. M.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00201.x
Subject(s) - atropine , quinidine , acetylcholine , auricular fibrillation , atrial fibrillation , medicine , muscarinic acetylcholine receptor , lung , anesthesia , pharmacology , cardiology , chemistry , receptor
Quinidine, amethocaine, Trasentin and atropine have been tested for their ability to stop atrial fibrillation produced in the heart‐lung preparation of the dog by stimulating the right atrium in the presence of acetylcholine. The results suggest that atropine acts by specifically antagonizing acetylcholine, but that amethocaine and Trasentin act chiefly by virtue of their quinidine‐like properties.