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A COMPARISON OF THE PITUITARY INHIBITORY EFFECTS OF PREDNISONE, PREDNISOLONE, AND HYDROCORTISONE
Author(s) -
HODGES J. R.,
VERNIKOS JOAN
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00199.x
Subject(s) - prednisolone , prednisone , hydrocortisone , endocrinology , medicine , corticosteroid , chemistry
Prednisone, prednisolone and hydrocortisone, administered in doses of 1 mg. daily for thirty days, depressed the growth rate of rats. Prednisolone and hydrocortisone caused atrophy of the adrenal glands and increased the relative weights of the thyroid glands and testes. The apparently similar effects produced by prednisone were not significant. The seminal vesicles were not affected significantly by prolonged administration of prednisone, prednisolone or hydrocortisone. Pretreatment of rats with these steroids prevented the adrenal ascorbic acid depletion normally caused by laparotomy under ether anaesthesia. Prednisolone was slightly more potent and prednisone was considerably less potent than hydrocortisone in producing these effects.