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THE ACTION OF DOPAMINE ON THE ARTERIAL BLOOD PRESSURE OF THE GUINEA‐PIG
Author(s) -
HORNYKIEWICZ O.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00197.x
Subject(s) - iproniazid , dopamine , amine oxidase , blood pressure , chemistry , guinea pig , tyramine , pharmacology , medicine , endocrinology , anesthesia , monoamine oxidase , biochemistry , enzyme
The depressor action of dopamine (β‐3:4‐dihydroxyphenylethylamine) upon the arterial blood pressure of the guinea‐pig has been studied. This effect begins without a latent period. It is often enhanced after the intravenous injection of iproniazid (Marsilid). The depressor response is sufficiently sensitive to serve as a method of bioassay of dopamine in microgram quantities. Observations on the depressor action of l ‐dopa have also been made. This effect is also enhanced by iproniazid; it begins after a latent period. Epinine (β‐3:4‐dihydroxyphenylethylmethylamine) caused a pressor response, followed by a fall of arterial blood pressure. No evidence was obtained in support of the suggestion that the two amines, which are oxidized at similar rates by amine oxidase, cause a fall of blood pressure after their conversion to an aldehyde by the action of amine oxidase.