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THE ACTION OF ATROPINE ON PANCREATIC SECRETION
Author(s) -
JUNQUEIRA L. C U.,
ROTHSCHILD HANNA A.,
VUGMAN I.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00193.x
Subject(s) - atropine , secretion , endocrinology , medicine , amylase , chemistry , glycine , zymogen , biology , biochemistry , amino acid , enzyme
The action of atropine, in preventing pancreatic secretion in response to a parasympathomimetic drug, is analysed. Atropine does not appear to affect the uptake of glycine by the pancreatic cell, or the incorporation of radioactive amino acids into the total pancreatic tissue proteins, or into the proteins of the zymogen granules. The rate of amylase resynthesis in stimulated glands is not affected by atropine. It is suggested that atropine blocks pancreatic secretion in rats by blocking the extrusion of zymogen granules.