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THE RENAL REMOVAL OF INJECTED [ 14 C]HISTAMINE FROM THE BLOOD IN DOGS
Author(s) -
LINDELL S.E.,
SCHAYER R. W.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00188.x
Subject(s) - histamine , diamine oxidase , kidney , urine , venous blood , chemistry , endocrinology , amine oxidase (copper containing) , medicine , histamine n methyltransferase , enzyme , histamine h2 receptor , biochemistry , receptor , antagonist
The amounts of [ 14 C]histamine in arterial blood, in renal venous blood and in urine during a steady intravenous infusion of [ 14 C]histamine were measured in five anaesthetized dogs. The extraction ratio for [ 14 C]histamine was 0.7 to 0.8, indicating that the histamine was efficiently taken up from the blood by the kidney. Only a small part (14 to 18%) of the [ 14 C]histamine removed from the blood by the kidney appeared in the urine as histamine. Evidence was obtained that [ 14 C]histamine was metabolized in the kidney not only by histaminase (diamine oxidase) but also by the histamine methylating enzyme.