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ANALGESIC ACTIVITY OF (+)‐1‐(3‐METHYL‐4‐MORPHOLINO‐2:2‐DIPHENYLBUTYRYL)PYRROLIDINE (R.875) IN STUDENT VOLUNTEERS
Author(s) -
CAHAL D. A.
Publication year - 1958
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1958.tb00186.x
Subject(s) - euphoriant , pyrrolidine , vomiting , analgesic , nausea , medicine , anesthesia , weakness , chemistry , anatomy , medicinal chemistry , psychiatry
(+)‐1‐(3‐Methyl‐4‐morpholino‐2:2‐diphenylbutyryl)pyrrolidine (R.875) raised the threshold to ischaemic pain in healthy human volunteers. The peak effect for all doses was reached after about 2 hr. The drug frequently caused nausea and vomiting but no euphoria. Muscular weakness was experienced by many subjects and was sometimes followed 1 to 2 hr. later by hiccup and muscle twitching, suggesting that R.875 may have an effect on striped muscle.