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INHIBITION BY MORPHINE OF THE RELEASE OF ACETYLCHOLINE FROM THE INTESTINE OF THE GUINEA‐PIG
Author(s) -
SCHAUMANN W.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb01372.x
Subject(s) - acetylcholine , liberation , morphine , guinea pig , chemistry , free nerve ending , pharmacology , endocrinology , biophysics , medicine , biology , biochemistry , in vitro
In experiments on the isolated small intestine of the guinea‐pig, morphine inhibited the release of acetylcholine (ACh) into the bath fluid. Experimental evidence is presented which suggests that the reduced release of ACh could not be explained by an inhibition of the synthesis of ACh, nor by stabilization of the bound form of ACh in the tissue. Apparently morphine reduces the excitability of postganglionic structures and thereby the liberation of ACh from nerve endings during the process of excitation.