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ANALGESIC ACTIVITY OF DIPIPANONE HYDROCHLORIDE IN STUDENT VOLUNTEERS
Author(s) -
CAHAL D. A.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb01368.x
Subject(s) - nausea , analgesic , anesthesia , tenderness , medicine , histamine , vertigo , vomiting , threshold of pain , hydrochloride , pharmacology , surgery , chemistry , organic chemistry
Dipipanone hydrochloride raised the threshold to ischaemic pain in healthy human volunteers. The lowest dose producing a significant rise in pain threshold was 10.0 mg. The peak effect for all doses was reached after about 2 hr. Side effects, the most common of which were drowsiness, nausea, and vertigo, are described and analysed. The drug was shown to be a histamine liberator and to cause pain and tenderness at injection sites.