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EXPERIMENTS WITH THE TRYPANOCIDAL COMPOUND “528” IN WEST AFRICA
Author(s) -
CHANDLER R. L.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb01360.x
Subject(s) - trypanosomiasis , trypanosoma vivax , cattle diseases , african trypanosomiasis , diminazene , veterinary medicine , drug , syringe , medicine , trypanosoma , zebu , toxicology , pharmacology , biology , virology , psychiatry
Studies have been made on the use of the chloride salt of “528” against cattle trypanosomiasis in Nigeria. Toxic effects, terminating in death, were produced in cattle receiving the drug at 5 mg./kg. and above. The maximum permissible dose for field use in Nigeria was found to be 2 mg./kg. The drug had an appreciable curative action against a syringe‐transmitted strain of T. congolense , but had no curative effect against two strains of T. vivax . It is concluded that “528” would be of very limited value in the treatment of cattle in West Africa, where T. vivax is the more important cause of cattle trypanosomiasis.