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THE ANTITUBERCULOUS ACTIVITY OF ETHYL THIOLESTERS WITH PARTICULAR REFERENCE TO DIETHYL DITHIOL ISO PHTHALATE
Author(s) -
DAVIES G. E.,
DRIVER G. W.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb00161.x
Subject(s) - isoniazid , streptomycin , pharmacology , chemistry , diethyl phthalate , phthalate , biochemistry , medicine , tuberculosis , antibiotics , organic chemistry , pathology
Diethyl dithiol iso phthalate exerts an antituberculous effect in mice comparable to that of isoniazid and streptomycin. It is effective when given in single doses, and against isoniazid‐resistant strains. It is most active when given subcutaneously either by injection or by absorption through the skin. Drug resistance has been demonstrated in mice, and isoniazid is active against such strains. The effects of this and other ethyl thiolesters are antagonized by their methyl analogues.