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THE EFFECT OF LYSERGIC ACID DIETHYLAMIDE, 5‐HYDROXYTRYPTAMINE, AND RELATED COMPOUNDS ON THE LIVER FLUKE, FASCIOLA HEPATICA
Author(s) -
MANSOUR T. E.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb00156.x
Subject(s) - lysergic acid diethylamide , fasciola hepatica , tryptamine , liver fluke , harmine , hallucinogen , lysergic acid , pharmacology , chemistry , yohimbine , biology , serotonin , biochemistry , receptor , helminths , immunology , antagonist
The rhythmical activity of the liver fluke, Fasciola hepatica , was stimulated by 5‐hydroxytryptamine and by lysergic acid diethylamide at very low concentrations. The effect was peripheral and was not mediated through the central ganglion. Other amines also stimulated rhythmical activity, the most potent being the indolamines. Bromolysergic acid diethylamide, and other analogues such as yohimbine, harmine, and dopamine, depressed rhythmical movement and antagonized the stimulant action of 5‐hydroxytryptamine and lysergic acid diethylamide. Evidence which suggests the presence of tryptamine receptors in the trematode is discussed.