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SUSCEPTIBILITY OF CERTAIN ENZYMES OF THE CENTRAL NERVOUS SYSTEM TO TETRODOTOXIN
Author(s) -
KURIAKI K.,
NAGANO H.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb00154.x
Subject(s) - tetrodotoxin , central nervous system , neuroscience , medicine , chemistry , biology , pharmacology
The neurotoxic poison from the roe of Fugu, a globe fish living in the waters of Japan, was investigated with reference to its effect on the main oxidation‐reduction systems, acetyl‐cholinesterase and choline‐acetylase in the brain of the guinea‐pig. It was found that the poison inhibited the choline‐acetylase activity, even in a concentration of 4.4 × 10 −7 . Acetyl‐cholinesterase and cytochrome‐c‐oxidase activities were also inhibited in concentration of 1.3 × 10 −5 and 0.8 × 10 −5 respectively.