Premium
OXIMES AND ATROPINE IN SARIN POISONING
Author(s) -
ASKEW BERYL M.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb00145.x
Subject(s) - sarin , atropine , methiodide , chemistry , pharmacology , antidote , nerve agent , pralidoxime , anesthesia , toxicology , toxicity , medicine , medicinal chemistry , acetylcholinesterase , biology , biochemistry , organic chemistry , enzyme
Three oximes, mono iso nitrosoacetone (MINA), pyridine‐2‐aldoxime methiodide (PAM) and diacetylmonoxime (DAM), have been examined in combination with atropine as antidotes in sarin poisoning. When treatment was administered 15 min. before sarin, atropine enhanced the protective effect of MINA and DAM 2 to 3 times and of PAM 9 to 10 times in mice and rats. In mice, rats, and guinea‐pigs, atropine increased by no more than 2 times the protective effect of all three oximes when given 30 sec. after sarin. Atropine given to monkeys 1 min. after sarin raised the LD50 approximately 3 times. When given in conjunction with MINA or DAM, the LD50 of sarin was raised 7 to 14 times.