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THE ENZYMATIC HYDROLYSIS OF IMIDAZOLEACRYLOYLCHOLINE (MUREXINE) AND IMIDAZOLEPROPIONYLCHOLINE (DIHYDROMUREXINE) BY VARIOUS CHOLINESTERASES
Author(s) -
GRELIS M. E.,
TABACHNICK I. I. A.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb00141.x
Subject(s) - cholinesterase , enzyme , guinea pig , choline , hydrolysis , biochemistry , enzymatic hydrolysis , chemistry , substrate (aquarium) , acetylcholinesterase , spleen , biology , endocrinology , immunology , ecology
Several choline esters, including the imidazoleacryloyl and imidazolepropionyl compounds, have been hydrolysed by cholinesterases from various sources. The imidazolepropionyl ester was metabolized by cholinesterases obtained from human plasma, ox spleen, ox serum, and guinea‐pig liver, but not by rat liver or bovine red cell cholinesterase. It is suggested the imidazolepropionylcholine or a closely related ester might be the natural substrate for “nonspecific” cholinesterase.