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SOME ACTIONS OF SUBSTITUTED CHOLINE PHENYL ETHERS, PARTICULARLY OF CHOLINE 2:6‐XYLYL ETHER
Author(s) -
EDGE N. D.,
MASON D. F. J.,
WYLLIE J. H.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb00140.x
Subject(s) - ether , choline , decamethonium , chemistry , curare , medicinal chemistry , acetylcholine , organic chemistry , pharmacology , biochemistry , medicine , receptor
Marked nicotine‐like stimulant properties are possessed by choline phenyl ether and choline o ‐tolyl ether, and to a decreasing extent by choline 2:6‐xylyl ether and choline 2:4:6‐mesityl ether. The compounds all show neuromuscular blocking properties, which are of short duration and pass from mainly decamethonium‐like to mainly curare‐like as more methyl groups are added to the phenyl nucleus. This series of compounds also possesses muscarinic, weak anti‐adrenaline and vasodilator properties, as well as long‐lasting local anaesthetic effects in the two compounds tested by intradermal injection.