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THE EFFECT OF DINITROPHENOL, HYPOXAEMIA AND ISCHAEMIA ON THE PHOSPHORUS COMPOUNDS OF THE DOG HEART
Author(s) -
FAWAZ G.,
HAWA E. S.,
TUTUNJI B.
Publication year - 1957
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1957.tb00133.x
Subject(s) - phosphocreatine , adenosine triphosphate , medicine , hypoxia (environmental) , cardiology , endocrinology , 2,4 dinitrophenol , heart rate , heart failure , dinitrophenol , chemistry , oxygen , energy metabolism , biochemistry , blood pressure , organic chemistry
The results reported in this paper indicate that dinitrophenol acts directly on the isolated heart, increasing its metabolic rate. It also produces heart failure associated with a low phosphocreatine content of the muscle but with no change in adenosine triphosphate, which may or may not be due to a relative hypoxia of the cardiac tissue. Experimental arterial hypoxaemia, if severe, produces a similar picture of heart failure with a decrease in phosphocreatine and no change in adenosine triphosphate. Ligation of the coronary arteries results in disappearance of the major part of the phosphocreatine within a few minutes regardless of whether or not ventricular fibrillation ensues; the adenosine triphosphate remains unchanged.