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THE ANTAGONISM BETWEEN 5‐HYDROXYTRYPTAMINE AND CERTAIN DERIVATIVES OF LYSERGIC ACID
Author(s) -
SAVINI E. C.
Publication year - 1956
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1956.tb01072.x
Subject(s) - citation , lysergic acid diethylamide , antagonism , confusion , pharmacology , computer science , library science , psychology , medicine , psychoanalysis , serotonin , receptor
The high pharmacological activity of 5-hydroxyThe doses, which, owing to a misunderstanding and tryptamine (5-HT) and its wide distribution in contrary to the usual custom, are given in terms of the the body suggest that it may play a part in normal weights of the salts, were injected in a uniform volume ,' physiological processes, but this is still a matter of 0.1 ml. at regular time intervals. The injections were for speculation. Very small amounts of 5-HT made slowly through the rubber cap of an injection tube similar to that described by Gaddum and Kwiatkowski cause vasoconstriction in the perfused ear of a (1938) and connected with the polythene cannula. The ,, rabbit, and this tissue was used in the work which perfusion fluid entered the air space in this tube in first ted to the isolation of 5-HT. It has been drops, and the rate of injection was regulated so as to .? suggested that an important action of 5-HT may keep the size of the drop approximately constant. In ._ be to modify the responses of tissues to other active this way changes in flow due to changes of pressure in