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OBSERVATIONS ON THE CHARACTER OF MERCURIAL DIURESIS
Author(s) -
DALE R. A.,
SANDERSON P. H.
Publication year - 1954
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1954.tb00843.x
Subject(s) - character (mathematics) , medical school , citation , diuresis , medicine , library science , medical education , computer science , mathematics , geometry , kidney
The very profound effect of mercurial diuretics on the excretion of sodium, chloride and water has been variously ascribed to an action on the proximal (Mudge, Foulks, and Gilman, 1949; Weston, Grossman, and Leiter, 1951) and the distal renal tubule (Duggan and Pitts, 1950). Comparatively little attention has been paid to the other constituents of urine. This paper describes the effect of mersalyl on the excretion of potassium, phosphate, hydrogen ion, ammonia, bicarbonate, uric acid, and creatinine in normal human subjects. Too little is known of the mechanisms governing the excretion of these substances to allow the data to be fitted into any single hypothesis. Nevertheless, the data seem worth recording, as they will have to be taken into account in any final hypothesis concerning the site and mode of action of the drug.