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THE NATURE OF CARDIAC SYMPATHIN IN THE DOG
Author(s) -
OUTSCHOORN AUBREY S.,
VOGT MARTHE
Publication year - 1952
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1952.tb01328.x
Subject(s) - citation , ceylon , library science , government (linguistics) , medicine , classics , history , computer science , philosophy , ancient history , linguistics
Since the demonstration by Peart (1949) that stimulation of the splenic nerves of the cat releases a " sympathin " consisting predominantly of noradrenaline with a small admixture of adrenaline, similar results have been obtained for liver sympathin by Mann and West (1950) and for the substance released by stimulation of the hypogastric nerves by the same authors (1951). Evidence on the nature of cardiac sympathin is available only for the frog's heart. Loewi (1936) demonstrated the actual release, on nervous stimulation, of a substance having the properties of adrenaline, and supporting evidence for its identity with adrenaline was obtained on extracts of heart muscle by Shaw (1938) and v. Euler (1946a). Cannon and Rosenblueth (1933) showed in the cat that stimulation of the cardio-accelerator strands from the right stellate ganglion caused the liberation into the blood mainly of-a sympathin with excitor properties (sympathin E). Since that work, the identification of the sympathin released on stimulation of the nervi accelerantes has, as far as we know, not been attempted in the mammal. Mammalian heart extracts examined by v. Euler (1946b) were shown to contain a sympathin differing in its properties from pure adrenaline; this was later shown in cattle to consist of a mixture of noradrenaline with from 8 to 20 per cent adrenaline (Goodall, 1950). The present paper is concerned with the nature of the sympathin released into the coronary blood of dogs on stimulation of the cardiac sympathetic nerves.