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THE INHIBITORY ACTION OF PALUDRINE ON THE SECRETION OF GASTRIC JUICE
Author(s) -
BURN J. H.,
VANE J. R.
Publication year - 1948
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1948.tb00399.x
Subject(s) - action (physics) , citation , gastric secretion , clinical pharmacology , medicine , order (exchange) , pharmacology , secretion , computer science , library science , business , physics , quantum mechanics , finance
Because excessive secretion of gastric juice is a common concomitant of chronic peptic ulcers, various workers have looked for substances having an inhibitory action. The secretion of HCl, though partly controlled by the vagus nerves, is peculiar in being stimulated by histamine and in being not greatly affected by atropine. The effect of atropine is described differently by different observers (Polland, 1930; Atkinson and Ivy, 1937; Gray, 1937; King, Comfort, and Osterberg, 1944). It appears to be more effective in abolishing the secretion produced by giving a meal than that produced by injecting histamine. Davenport (1940), and later Rehm and Enelow (1945), investigated the effect of sodium thiocyanate; when given intravenously to dogs in sufficient amount, it was found to inhibit the secretion of HC1 completely. Recently Babkin and Karp (1947) have observed that the two antimalarial substances quinine and mepacrine (atebrin), when injected intravenously into dogs, depressed the secretion of gastric juice produced by stimulation of the vagus nerves. The doses they used were large in relation to the doses ordinarily given to man; thus a dog of 10 kg. received 0.2 g. quinine bisulphate or 75 mg. mepacrine. When secretion was produced by the injection of histamine, neither quinine nor mepacrine affected it. Recently a simple method of examining substances for an inhibitory action on gastric secretion has been developed in this laboratory by Wood (1948); cats are used, anaesthetized by cyclopropane or pentobarbitone (nembutal). The only essential point in which the method differs from that proposed by Lim (1923), and modified by Roth and Ivy (1944), is that histamine solution has been infused into the jugular vein at a uniform rate for periods up to 7 hours. In order to obtain a uniform infusion, a pump designed and made by Dr. E. H. J. Schuster has been used, with which a reasonably steady secretion of gastric juice has been obtained. The oesophagus was tied in the neck and not at the cardiac orifice, to avoid the vagi.