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ACTIVATION OF PALUDRINE
Author(s) -
HAWKING FRANK,
PERRY WALTER L. M.
Publication year - 1948
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1948.tb00394.x
Subject(s) - hawking , citation , classics , philosophy , medicine , physics , library science , history , computer science , quantum mechanics , entropy (arrow of time)
Tonkin (1946), in this laboratory, investigated the effect of adding paludrine to tssue cultures containing exo-erythrocytic forms of Plasmodium gallinaceum and found that the parasites developed in the highest concentrations (2-5 mg. per litre) tolerated by the macrophages. Since this concentration is many times greater than that which is believed to be present in the plasma during human therapy (probably about 0.3 mg. per litre), and since Davey (1946) had reported that paludrine was highly effective in curing the exo-erythrocytic infections of P. gallinaceum in chickens, as well as the endo-erythrocytic ones, Tonkin's finding was surprising and led to further investigations, which were undertaken with both P. gallinaceum and P. cynomolgi. A preliminary note describing some of the results was published by Hawking (1947).