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THE ANTIBACTERIAL ACTIVITY OF SOME SYNTHETIC COMPOUNDS RELATED TO PENICILLIN
Author(s) -
BROWNLEE GEORGE,
WOODBINE MALCOLM
Publication year - 1948
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1948.tb00391.x
Subject(s) - george (robot) , copp , medicine , classics , library science , philosophy , art history , art , chemistry , computer science , heme , biochemistry , enzyme , heme oxygenase
Concurrently with attempts to synthesize penicillin, the chemistry' and synthesis of which have been described by du Vigneaud, Carpenter, Holley, Livermore, and Rachele (1946), the antibacterial activity of compounds, or derivatives of compounds, known or postulated as parts of the penicillin molecule, has also been investigated. The compounds examined here may be conveniently classified into groups based on: penicillamines (I) (Copp and Wilkinson, 1947a; Duffin and Wilkinson, 1947a, b; Wilkinson 1947a); thiazolidine-4-carboxylic acids (IL) (Wilkinson, 1947b); oxazolones (III) (Copp and Wilkinson, 1947b, c); derivatives of glycine (IV), and a miscellaneous group of intermediate and associated compounds (Copp, 1947) (included in Table II).