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Falsely increased plasma lactate concentration due to ethylene glycol poisoning in 2 dogs
Author(s) -
Hopper Kate,
Epstein Steven E.
Publication year - 2013
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/j.1476-4431.2012.00825.x
Subject(s) - ethylene glycol , medicine , metabolite , toxicity , plasma concentration , point of care , ethylene glycol poisoning , chromatography , anesthesia , pharmacology , chemistry , metabolic acidosis , pathology , organic chemistry
Objective To describe false increases in plasma lactate concentration measured on point‐of‐care analyzers in 2 dogs with ethylene glycol (EG) intoxication. Case Summary Two dogs presenting with EG intoxication had extreme increases of plasma lactate concentrations recorded on a point‐of‐care machine. Laboratory analysis by spectrophotometry of lactate concentration determined these lactate measurements to be erroneous. False increases in plasma lactate concentration were demonstrated in 2 out of 3 point‐of‐care machines tested. New or Unique Information Provided Glycolate, a toxic metabolite of EG, can interfere with the measurement of plasma lactate by some analyzers and this may delay the correct diagnosis of EG toxicity if not recognized.