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Low tidal volume ventilation in healthy dogs
Author(s) -
Oura Trisha,
Rozanski Elizabeth A.,
Buckley Gareth,
Bedenice Daniela
Publication year - 2012
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/j.1476-4431.2012.00749.x
Subject(s) - medicine , tidal volume , anesthesia , ventilation (architecture) , pulmonary compliance , acidosis , mechanical ventilation , respiratory physiology , respiratory minute volume , respiratory system , mean airway pressure , mechanical engineering , engineering
Objective To determine if low tidal volume ( V T ) ventilation is associated with the development of respiratory acidosis and changes in lung function in healthy dogs. Design Randomized prospective experimental cross‐over study. Setting Pulmonary function laboratory at a university teaching hospital. Animals Five healthy B eagle dogs. Interventions Dogs were anesthetized and randomly mechanically ventilated with V T of 6, 8, 10, 12, and 15 m L /kg while maintaining a constant minute volume. Measurements and Main Results Arterial blood gases and pulmonary mechanics were collected after 15 minutes of equilibration at each V T . Repeated measures ANOVA was used to determine the effect of V T with a P ‐value of <0.05 considered significant, and a P earson product moment was used to determine correlation between V T and p H and P a CO 2 . V T had a significant effect on P a CO 2 ( P < 0.001) and on p H ( P < 0.001) with lower V T being associated with higher P a CO 2 and lower p H . There was a strong correlation between V T and P a CO 2 ( r = –0.87) and V T and p H ( r = 0.83). Increased airway pressures and pulmonary compliance were associated with increasing V T . Conclusions There is a predictable decrease in the p H , decrease in airway pressure, decrease in compliance, and increase in the P a CO 2 associated with lower V T . Low V T ventilation is well tolerated in healthy dogs; the role of low V T ventilation in dogs with acute lung injury/acute respiratory distress syndrome as well as the influence of positive end expiratory pressure requires further evaluation.