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4‐Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats
Author(s) -
Tart Kelly M.,
Powell Lisa L.
Publication year - 2011
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/j.1476-4431.2011.00638.x
Subject(s) - cats , medicine , ethylene glycol , toxicity , pharmacology , anesthesia , toxicology , chemistry , biology , organic chemistry
Abstract Objective– To describe the clinical experience and therapeutic use of fomepizole (4‐methylpyrazole [4‐MP]) in 3 cats with naturally occurring ethylene glycol (EG) toxicity. Case or Series Summary– All cats were documented to be EG positive by an ethylene glycol test kit. This report describes the dose of 4‐MP used, available clinicopathological data, and clinical progression during hospitalization. All patients survived to discharge. New or Unique Information Provided– IV use of 4‐MP at 125 mg/kg as an initial dose and 31.25 mg/kg at 12, 24, and 36 hours is safe and effective for treatment of naturally occurring EG toxicity in cats. Increased HCO 3 concentrations were noted after IV use of 4‐MP. This is the first report documenting the successful treatment of naturally occurring EG intoxication in cats with 4‐MP.