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Partial pressure of end‐tidal CO 2 sampled via an intranasal catheter as a substitute for partial pressure of arterial CO 2 in dogs
Author(s) -
Pang D.,
Hethey J.,
Caulkett N. A.,
Duke T.
Publication year - 2007
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/j.1476-4431.2007.00213.x
Subject(s) - medicine , anesthesia , arterial catheter , catheter , arterial blood , confidence interval , blood pressure , nose , surgery
Objective: To demonstrate correlation and clinical usefulness of the partial pressure of end‐tidal CO 2 (ETCO 2 ) measurement by nasal catheter placement in sedated dogs with and without concurrent nasal oxygen administration as a substitute for partial pressure of arterial CO 2 (PaCO 2 ). Design: Prospective, cross‐over trial. Setting: University of Saskatchewan veterinary research laboratory. Animals: Six cross‐breed dogs with a mean (±SD) weight of 29.1±4.03 kg. Interventions: All dogs were sedated with 5 μg/kg medetomidine intravenously (IV) and an arterial catheter was placed in a dorsal pedal artery for removal of blood for gas analysis. A nasal catheter was placed in the ventral meatus and connected to a capnometer for ETCO 2 measurements in all dogs. Dogs receiving supplemental nasal oxygen had a second nasal catheter placed in the contralateral naris. Measurements and main results: In the group without nasal oxygen supplementation, the ETCO 2 measurement underestimated (negative bias) the PaCO 2 by −2.20 mmHg with limits of agreement (95% confidence interval) of −5.79, 1.39 mmHg. In the group receiving oxygen supplementation, ETCO 2 measurement underestimated (negative bias) the PaCO 2 by −2.46 mmHg with limits of agreement (95% confidence interval) of −8.42, 3.50 mmHg. Conclusions: The results of this study demonstrate that ETCO 2 monitoring via a nasal catheter provides a clinically acceptable substitute to arterial blood gas analysis as a means of monitoring ventilation in healthy, sedated dogs. The limits of agreement were within acceptable limits with and without concurrent insufflation of oxygen.