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Fluorescein leakage of the optic disc: time course in primary open‐angle glaucoma
Author(s) -
Plange Niklas,
Kaup Marion,
Doehmen Benjamin,
Remky Andreas,
Arend Kay Oliver
Publication year - 2010
Publication title -
ophthalmic and physiological optics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.147
H-Index - 66
eISSN - 1475-1313
pISSN - 0275-5408
DOI - 10.1111/j.1475-1313.2010.00717.x
Subject(s) - fluorescein , open angle glaucoma , optic disc , glaucoma , optic nerve , ophthalmology , leakage (economics) , medicine , fluorescence , optics , physics , macroeconomics , economics
Purpose: To identify and quantify the time course of fluorescein leakage of the optic nerve head in primary open‐angle glaucoma (POAG) and controls. Methods: Twenty patients with POAG (aged 58 ± 10 years) and 14 controls (aged 51 ± 12 years, p = 0.07) were included in a prospective study. Fluorescein leakage of the optic disc was quantified using digital image analysis. A new leakage ratio (fluorescence of the optic disc divided by fluorescence of the surrounding retina) was defined and fluorescein leakage was quantified at 7–8, 9–10, 11–12, and 13–14 min after injection of 2.5 cc sodium fluorescein (10%). Results: The fluorescein leakage exhibited a significantly different time course with higher leakage ratio values in POAG compared to controls (7–8 min: 1.24 ± 0.32 vs 1.16 ± 0.12; 9–10 min: 1.37 ± 0.37 vs 1.19 ± 0.1; 11–12 min: 1.38 ± 0.36 vs 1.24 ± 0.13; 13–14 min: 1.44 ± 0.36 vs 1.27 ± 0.13; p = 0.004). The change in optic disc fluorescence from 7–8 min to 9–10 min was significantly higher in POAG compared to controls (0.13 ± 0.09 vs 0.03 ± 0.07; p = 0.002). Conclusion: The time course of fluorescein leakage is significantly different in POAG compared to controls. This might reflect damage of the optic disc vasculature related to increased vascular permeability.