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Dehydration of hydrogel contact lenses in vitro and in vivo
Author(s) -
Efron Nathan,
Young Graeme
Publication year - 1988
Publication title -
ophthalmic and physiological optics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.147
H-Index - 66
eISSN - 1475-1313
pISSN - 0275-5408
DOI - 10.1111/j.1475-1313.1988.tb01055.x
Subject(s) - dehydration , contact lens , lens (geology) , refractometer , in vivo , materials science , optics , chemistry , ophthalmology , biomedical engineering , analytical chemistry (journal) , refractive index , chromatography , medicine , physics , biology , optoelectronics , biochemistry , microbiology and biotechnology
An attempt was made to derive a model for predicting the extent of hydrogel lens dehydration in vivo (ΔW v ) by using a contact lens refractometer to (1) measure the water content (W) of eight lensus ranging from 36.5 to 85.8% water before and after 90 min lens wear by six subjects; and (2) measure the rate of dehydration of the same lenses in vitro (ΔW 1 ), in a controlled, randomized, double‐masked experiment. A significant correlation was demonstrated between W and the rate of change of ΔW 1 (the dehydration rate, D), whereby lenses of higher water content dehydrate at a slower rate. No correlation was found between W and Δ W v or between D and ΔW v , thus precluding the development of a predictive model. Possible reasons for this failure, and directions for further research, are discussed