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A TEST BED FOR OCULAR DRUGS *
Author(s) -
Wigham Chris,
Hodson Stuart
Publication year - 1986
Publication title -
ophthalmic and physiological optics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.147
H-Index - 66
eISSN - 1475-1313
pISSN - 0275-5408
DOI - 10.1111/j.1475-1313.1986.tb01133.x
Subject(s) - corneal endothelium , endothelium , in vitro , barrier function , cornea , medicine , ophthalmology , transparency (behavior) , pharmacology , chemistry , biology , microbiology and biotechnology , computer science , biochemistry , computer security
— Corneal endothelium plays a vital role in maintaining corneal transparency. We describe here a new in vitro technique for detecting acute effects of ocular drugs on corneal endothelium from animal species and post‐mortem human tissue. The technique is based upon trans‐endothelial electrical activity and leads as a consequence, to rapid, unambiguous, quantitative assessments of pharmacological effects upon endothelial barrier function and fluid pump activity.