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Experimental Device for Simulating Traumatic Brain Injury Resulting from Linear Accelerations
Author(s) -
Gilchrist Michael D.
Publication year - 2004
Publication title -
strain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.477
H-Index - 47
eISSN - 1475-1305
pISSN - 0039-2103
DOI - 10.1111/j.1475-1305.2004.00168.x
Subject(s) - traumatic brain injury , neurophysiology , brain tissue , brain trauma , human brain , neuroscience , acceleration , computer science , biomedical engineering , physical medicine and rehabilitation , medicine , psychology , physics , classical mechanics , psychiatry
Abstract:  Various methods are used to model and analyse traumatic brain injuries (TBI) in human beings. These include volunteer and cadaver experiments, anthropomorphic dummies, physical models, computational models and mathematical models. The pathophysiological response to mechanical impact of the human central nervous system and of in vivo neural tissue, is most realistically analysed using animal models, which provide the best surrogate for the human brain. During non‐fatal impacts, a mechanical insult may trigger a cascade of physiological processes, many mediated by neurochemicals within the neural tissue which will, in turn, control the depth and extent of the brain injury. This paper reports the development of a novel experimental device which can apply different linear acceleration impacts directly to in vivo neural tissue in a manner which permits the experimental analysis of non‐fatal TBI of varying severity.

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