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Validation of the BCIS ‐1 M yocardial J eopardy score using cardiac magnetic resonance perfusion imaging
Author(s) -
Morton Geraint D. J.,
Silva Kalpa,
Ishida Masaki,
Chiribiri Amedeo,
Indermuehle Andreas,
Schuster Andreas,
Redwood Simon,
Nagel Eike,
Perera Divaka
Publication year - 2013
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2012.01167.x
Subject(s) - medicine , cardiology , coronary artery disease , magnetic resonance imaging , perfusion , perfusion scanning , receiver operating characteristic , cardiac magnetic resonance imaging , radiology
Summary The recently described angiographic BCIS ‐1 M yocardial J eopardy Score ( BCIS ‐ JS ) provides a semi‐quantitative estimate of the extent of coronary artery disease ( CAD ). It is simple to use and applicable to all patients including those with bypass grafts. Our objective was to validate the BCIS ‐ JS by evaluating its correlation with myocardial ischaemic burden and its accuracy at predicting a prognostic ischaemic threshold. Seventy‐five patients with angina and known or suspected CAD referred for coronary angiography prospectively underwent high‐resolution CMR perfusion imaging. There was good correlation between the BCIS ‐ JS and myocardial ischaemic burden: r = 0·75, P <0·0001. Area under the ROC curve for BCIS ‐ JS to detect ≥12% myocardial ischaemic burden was 0·87 (95% CI 0·78–0·96). BCIS ‐ JS ≥6 predicted ≥12% myocardial ischaemic burden with a sensitivity of 68% and a specificity of 91%. The BCIS ‐ JS correlates well with myocardial ischaemic burden. A BCIS ‐ JS ≥6 predicts the prognostically important ischaemic threshold of 12% with high specificity. These findings demonstrate that the BCIS ‐ JS has functional relevance and support its utility for classification of CAD burden in clinical trials and in clinical practice.