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Intravenous adrenaline infusion causes vasoconstriction close to an intramuscular microdialysis catheter in humans
Author(s) -
Vedung Torbjörn,
Jorfeldt Lennart,
Henriksson Jan
Publication year - 2010
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2010.00955.x
Subject(s) - medicine , microdialysis , anesthesia , blood flow , placebo , catheter , vasoconstriction , skeletal muscle , perfusion , epinephrine , surgery , pathology , dopamine , alternative medicine
Summary Aim: To test if a small muscle injury influences the vascular reactivity to adrenaline in human skeletal muscle. Methods: Blood flow was measured by 133 Xenon clearance in the gastrocnemius muscle of eight male subjects at basal and during i.v. infusion of adrenaline (0·1 nmol kg −1 min −1 ) or placebo. Measurements were done with (expts 2 and 3) or without (expt 1) the influence of a small muscle injury induced by inserting a microdialysis catheter. 133 Xenon was administered either (expt 1) conventionally into the muscle via a fine needle, or (expts 2 and 3) through a fine tube close to the inserted microdialysis catheter. Expt 3 (control expt) was identical to expt 2 except that placebo was infused instead of adrenaline. Mean ± SEM, n = 8. Results: The blood flow tended to increase during the adrenaline infusion in expt 1 (1·17 ± 0·10 to 1·39 ± 0·15, N.S.), whereas it decreased during the adrenaline infusion in expt 2, from 1·39 ± 0·14 to 1·03 ± 0·14 ml min −1 100 g tissue −1 ( P <0·001). The blood flow change in response to adrenaline infusion was significantly different in expt 1 and expt 2 ( P <0·05). Blood flow also decreased during the placebo infusion in expt 3 (1·15 ± 0·10 to 1·00 ± 0·09, P <0·01), but this decrease was significantly smaller than in response to the adrenaline infusion in expt 2, P <0·01. Conclusion: The present results are consistent with the hypothesis that the small muscle injury caused by the inserted microdialysis catheter influences the vascular reactivity to adrenaline in a vasoconstrictive direction.