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Cerebral perfusion information obtained by dynamic contrast‐enhanced phase‐shift magnetic resonance imaging: comparison with model‐free arterial spin labelling
Author(s) -
Wirestam Ronnie,
Lindgren Emelie,
Van Westen Danielle,
Markenroth Bloch Karin,
Ståhlberg Freddy,
Knutsson Linda
Publication year - 2010
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2010.00947.x
Subject(s) - medicine , cerebral blood flow , magnetic resonance imaging , nuclear medicine , perfusion , grey matter , nuclear magnetic resonance , perfusion scanning , gadolinium , white matter , cardiology , radiology , physics , chemistry , organic chemistry
Summary Phase‐shift time curves following a bolus injection of gadolinium contrast agent were registered for grey‐matter regions and large vessels in 14 subjects. Deconvolving a tissue phase‐shift curve with a phase‐based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area‐to‐height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model‐free arterial spin labelling (ASL). The phase‐based relative CBF estimates showed good linear correlation with ASL‐based CBF ( r = 0·82). Grey‐matter MTT was 4·9 ± 1·1 s (mean ± SD).