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Simultaneous quantification of myocardial perfusion, oxidative metabolism, cardiac efficiency and pump function at rest and during supine bicycle exercise using 1‐ 11 C‐acetate PET – a pilot study
Author(s) -
Sörensen Jens,
Valind Sven,
Andersson Lars G.
Publication year - 2010
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2010.00938.x
Subject(s) - medicine , supine position , cardiac output , cardiac function curve , heart rate , perfusion , cardiology , blood flow , diastole , hemodynamics , nuclear medicine , blood pressure , heart failure
Summary Background: PET using 1‐ 11 C‐acetate (ACE‐PET) applied at rest is used for measuring absolute myocardial blood flow (MBF) and oxidative metabolic rate (k mono ). We evaluated the feasibility of quantitative ACE‐PET during exercise. Methods: Five endurance athletes underwent dynamic PET scanning at rest and during supine bicycle stress. Exercise was maintained at a workload of 120 Watt for 17 min. The rate‐pressure product (RPP) was recorded repeatedly. MBF, k mono in left (LV) and right (RV) ventricular wall, cardiac output (CO), cardiac efficiency and a lung uptake value reflecting left heart diastolic pressures were calculated from the PET data using previously validated models. Results: MBF increased from 0·71 ± 0·17 to 2·48 ± 0·25 ml min −1 per ml, LV‐k mono from 0·050 ± 0·005 to 0·146 ± 0·021 min −1 , RV‐k mono from 0·023 + 0·006 to 0·087 + 0·014 min ‐1 , RPP from 4·7 ± 0·8 to 13·2 ± 1·4 mmHg × min −1 × 10 3 and Cardiac Output from 5·2 ± 1·1 to 12·3 ± 1·2 l min −1 (all P < 0·001). Cardiac efficiency was unchanged ( P = 0·99). Lung uptake decreased from 1·1 ± 0·2 to 0·6 ± 0·1 ml g −1 ( P < 0·001). Discussion: A number of important parameters related to cardiac function can be quantified non‐invasively and simultaneously with a short scanning protocol during steady state supine bicycling. This might open up new opportunities for studies of the integrated cardiac physiology in health and early asymptomatic disease.