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Extended NO analysis in a healthy subgroup of a random sample from a Swedish population
Author(s) -
Högman Marieann,
Lafih Jaroslava,
Meriläinen Pekka,
Bröms Kristina,
Malinovschi Andrei,
Janson Christer
Publication year - 2009
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2008.00831.x
Subject(s) - medicine , asthma , exhalation , copd , exhaled nitric oxide , population , subgroup analysis , diffusing capacity , cystic fibrosis , pulmonary disease , respiratory disease , cardiology , lung , spirometry , meta analysis , lung function , anesthesia , environmental health
Summary Introduction: There is an interest in modelling exhaled nitric oxide (NO). Studies have shown that flow‐independent NO parameters i.e. NO of the alveolar region (C A NO), airway wall (C aw NO), diffusing capacity (D aw NO) and flux (J aw NO), are altered in several disease states such as asthma, cystic fibrosis, alveolitis and chronic obsmuctive pulmonary disease (COPD). However, values from a healthy population are missing. Objectives: To calculate NO parameters in a healthy population by collecting NO values at different exhalation flow rates. Methods: A random sample from the ECRHS II study was investigated. Among the 281 subjects that had performed a bronchial hyperreactivity (BHR)‐test, FEV 1·0 , IgE and NO‐analyses 89 were found to be healthy. Results: There were no differences in F E NO 0·05 or NO parameters between men and women. There were weak correlations between height and both F E NO 0·05 ( r = 0·23, P = 0·03) and C aw NO ( r = 0·22, P = 0·04). There was also a correlation between age and C A NO ( r = 0·28, P = 0·007). When controlled for gender, this correlation was more powerful in women ( r = 0·51, P = 0·001) but did not remain for male subjects. Conclusion: Extended NO analysis is a simple non‐invasive tool that gives by far more information than F E NO 0·05 . Based on our results, we suggest that the values for healthy subjects should be considered to fall between the following ranges: F E NO 0·05 , 10–30 ppb; C aw NO, 50–250 ppb; D aw NO, 5–15 ml s −1 ; J aw NO, 0·8–1·6 nl s −1 ; and C A NO, 0–4 ppb. Values outside these intervals indicate the need for further investigation to exclude a state of disease.